{"id":10592,"date":"2021-05-31T13:54:06","date_gmt":"2021-05-31T10:54:06","guid":{"rendered":"https:\/\/mozartcultures.com\/en\/?p=10592"},"modified":"2021-05-31T15:22:07","modified_gmt":"2021-05-31T12:22:07","slug":"dont-drink-coffee-if-you-want-to-heal-caffeine-drug-interactions","status":"publish","type":"post","link":"https:\/\/mozartcultures.com\/en\/dont-drink-coffee-if-you-want-to-heal-caffeine-drug-interactions\/","title":{"rendered":"Don’t drink coffee if you want to heal: Caffeine-drug interactions"},"content":{"rendered":"
\n
Caffeine, which we take from many foods in our daily lives,even in small amounts, can affect our medications when it reaches certain doses. So, what is caffeine? How does it affect the body? How can it change the effects of drugs? For answers, keep reading.<\/h5>\n<\/blockquote>\n

What is caffeine?<\/h1>\n

\"\"
Wikipedia, the free encyclopedia. (2021, February 7). Kafein [Image]. Wikipedia. https:\/\/tr.wikipedia.org\/wiki\/Kafein<\/figcaption><\/figure>Caffeine is one of the most widely used pharmacies in the world. Caffeine includes a variety of analgesics, dietary\/nutritional supplements, and cold\/flu medications. It is also included in the composition of a number of pharmacological preparations and over-the-counter drugs. It can cause side effects such as irritability, insomnia, diuresis, arrhythmia, headache, tachycardia, respiratory, so it should be taken in limited quantities.<\/p>\n

 <\/p>\n

The stimulating mechanism of caffeine<\/h2>\n
\"\"
Adriana Azor. (2020, March 21). 8 Easy Things You Did Not Know Your Brain Needs [Image]. Medium. https:\/\/medium.com\/swlh\/8-easy-things-you-did-not-know-your-brain-needs-44a1aff51d60<\/figcaption><\/figure>\n

The primary mechanism of action of caffeine is the antagonism of adenosine receptors in the brain. Caffeine with this effect temporarily prevents or alleviates drowsiness and thus maintains vigilance, also causes an increase in blood pressure. Caffeine from coffee or other consuming sources is absorbed by the small intestine generally within\u00a0 45 minutes of digestion and is distributed throughout the body tissues. It is metabolized in the liver into three main substances: paraxanthin (84%), theobromine (12%), and theophylline (4%).<\/p>\n

    \n
  • Coffee and cocoa beans are especially rich in caffeine and theobromines, so when they are consumed in excess, they are associated with certain health problems such as migraines, hypertension, and medications.<\/li>\n
  • The amount of caffeine in a cup of coffee (150ml) is 60 – 120 mg. 71% of the caffeine in an American diet comes from coffee.<\/li>\n
  • If the daily use exceeds 500 – 600 mg (4-7 cups of coffee), it may cause serious health problems.<\/li>\n<\/ul>\n
    \"\"
    100% High-Quality Cocoa Beans For Sale. (n.d.). [Image]. Turkish Ali Baba. https:\/\/turkish.alibaba.com\/product-detail\/100-high-quality-cocoa-beans-for-sale-62011722288.html<\/figcaption><\/figure>\n\n\n\n\n\n\n\n
    Food<\/b><\/td>\nPortion and caffeine amounts (mg)<\/b><\/td>\n<\/tr>\n
    Chocolate(classic)<\/td>\n50 gr\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 3-63<\/td>\n<\/tr>\n
    Wafer<\/td>\n1 bar(46gr)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 5<\/td>\n<\/tr>\n
    Dark Chocolate<\/td>\n1 bar(41gr)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 31<\/td>\n<\/tr>\n
    Chocolate ice cream<\/td>\n50gr\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2-5<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

     <\/p>\n

    How do caffeine and drugs interact?<\/h1>\n

     <\/p>\n

    CYP450<\/strong> is an enzyme that metabolizes drugs.<\/p>\n

    They also metabolize environmental toxins, dietary components, and various endogenous substances (e.g., steroids, prostaglandins) that are produced within the body, and the activity of these substances is also a factor in determining the speed at which various drugs are cleared from the body.<\/p>\n

    Usually, CYP450 enzymes inactivate a drug or compound, but sometimes they make it more active.<\/p><\/blockquote>\n

    Most of the caffeine you ingest is metabolized by a CYP450 liver enzyme called \u201cCYP1A2.\u201d\u00a0 CYP1A2 enzyme, \u201cdemethylate\u201d<\/strong> caffeine molecules; transforming them into other substances. Other drugs metabolized by this enzyme include theophylline, warfarin, and several antidepressants and antipsychotics.<\/p>\n

    When caffeine is introduced, there is less enzyme available to metabolize these drugs.\u00a0 What this means is that each acts as a metabolic inhibitor of the other, slowing down the speed with which the body can \u201cbreak down\u201d or eliminate the drugs.\u00a0 The result is that the blood level of these drugs, or of caffeine, or of both increases.<\/p>\n

    For example<\/strong>, a woman who was a heavy coffee drinker who was also taking clozapine (an anti-schizophrenic medication) was found to have about 2 \u00bd times higher blood levels of the drug when she took caffeine. Because schizophrenic patients commonly consume remarkably high doses of caffeine, such interactions could conceivably constitute a relatively common problem for patients taking that medication.<\/p>\n

    \"\"
    Clozapine. (n.d.). [Image]. Prescriptiongiant. https:\/\/prescriptiongiant.com\/product\/clozapine\/<\/figcaption><\/figure>Caffeine also may cause therapeutic failure in patients receiving lithium (an antipsychotic), may cause toxic reactions in clozapine (another antipsychotic), may augment the efficacy of aspirin and acetaminophen (Tylenol) and may have no significant consequences, despite metabolic interactions, on the effects of mexiletine (an antiarrhythmic).<\/p>\n

     <\/p>\n

    In summary, the medications you are taking, the foods you are eating, even the cigarettes you are smoking, can change the way caffeine is metabolized by your body.\u00a0And caffeine can also change the way certain other drugs are metabolized.<\/em><\/p>\n

     <\/p><\/blockquote>\n\n\n\n\n\n\n\n\n\n\n\n
    Class of <\/b>Drug<\/b><\/td>\nGeneric Name<\/b><\/td>\n<\/tr>\n
    Antiandrogens<\/td>\nFlutamide<\/td>\n<\/tr>\n
    Antidepressants<\/td>\nAmitriptyline Clomipramine Fluvoxamine Mianserin Imipramine<\/td>\n<\/tr>\n
    Antipsychotics<\/td>\nClozapine Haloperidol Olanzapine<\/td>\n<\/tr>\n
    Cardiovascular Drugs and Anticoagulants<\/td>\nLidocaine Mexiletine Propafenone Propranolol Triamterene Verapamil Warfarin<\/td>\n<\/tr>\n
    Cholinesterase Inhibitors<\/td>\nTacrine<\/td>\n<\/tr>\n
    Local Anesthetic<\/td>\nRopivacaine<\/td>\n<\/tr>\n
    Nonsteroidal Anti-inflammatory Drugs<\/td>\nAcetaminophen Phenacetin Methotrexate<\/td>\n<\/tr>\n
    Quinolones<\/td>\nPefloxacin<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    List of drugs whose metabolism is partially or entirely dependent on CYP (1A2), which means that they will be metabolized more slowly when caffeine is used.\u00a0<\/em><\/p>\n

    Some Drugs and Interactions<\/h1>\n

    1.Coffee<\/b><\/u><\/h2>\n
    \"\"
    Tiffany Lukk. (2020, September 29). Where to Buy Coffee Beans Locally [Image]. Mspmag. https:\/\/mspmag.com\/eat-and-drink\/where-to-buy-coffee-beans-mn\/<\/figcaption><\/figure>\n\n\n\n\n\n\n\n\n\n\n\n
    DRUG<\/b><\/td>\nEffect<\/b> After<\/b> Interact\u0130on<\/b> With<\/b> Coffee<\/b><\/em><\/td>\n<\/tr>\n
    Anagrelide<\/td>\nEdema,stroke,hypotension,arrhythmia<\/td>\n<\/tr>\n
    Asenapine<\/td>\nBlood contraction increases to toxic level<\/td>\n<\/tr>\n
    Bendamustine<\/td>\nAnemia, infection<\/td>\n<\/tr>\n
    Dipyridamole<\/td>\nRecure more doses to work<\/td>\n<\/tr>\n
    Hydroxyprogesterone<\/td>\nDecreases the effect of caffeine<\/td>\n<\/tr>\n
    Lithium<\/td>\nCan cause lithium toxication<\/td>\n<\/tr>\n
    Paracetamol<\/td>\nIncreases the reabsorption of the drug<\/td>\n<\/tr>\n
    Rasagiline<\/td>\nCause serious side effects<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    <\/h2>\n

    2.Chocolate<\/b><\/u><\/h2>\n
    \"\"
    Where does chocolate come from ? (n.d.). [Image]. Baamboozle. https:\/\/www.baamboozle.com\/game\/345765<\/figcaption><\/figure>\n\n\n\n\n\n\n\n\n\n
    DRUG<\/b><\/td>\nEffect<\/b> After<\/b> Interaction<\/b> With<\/b> Chocolate<\/b><\/td>\n<\/tr>\n
    Acetaminophen<\/td>\nIncrease in absorption of drug<\/td>\n<\/tr>\n
    Theophylline<\/td>\nIncrease the toxication of drug<\/td>\n<\/tr>\n
    Antiaritmics<\/td>\nArrhythmia risk<\/td>\n<\/tr>\n
    Ephedrine<\/td>\nIrritability and anxiety increases<\/td>\n<\/tr>\n
    Methylphenidate<\/td>\nEffects increase<\/td>\n<\/tr>\n
    Zolpidem<\/td>\nEffects decreases<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    <\/h2>\n

    3.Tea<\/b><\/u><\/h2>\n
    \"\"
    Tea. (2021b). [Image]. Https:\/\/Tr.Pinterest.Com\/Pin\/431641945520844064\/. https:\/\/images.app.goo.gl\/jo5vkFrQvd3SnGiN8<\/figcaption><\/figure>\n\n\n\n\n\n
    DRUG<\/b><\/td>\nEffect<\/b> After<\/b> Interact\u0130on<\/b> With<\/b> Tea<\/b><\/td>\n<\/tr>\n
    Theophylline<\/td>\nTheophylline toxication<\/td>\n<\/tr>\n
    Iron-containing preperations<\/td>\nReabsorption of iron decreases<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

     <\/p>\n

     <\/p>\n

    REFERENCES<\/b><\/u>
    \nJuan A. Carrillo and Julio Benitez. (2000).\u00a0 \u201cClinically Significant Pharmacokinetic Interactions Between Caffeine and Medications,\u201d Clinical<\/u> Pharmacokinetics<\/u>,<\/em> 39<\/em>(2); 127-153<\/p>\n

    Jeppesen U, Gram LF, Vistisen K, Loft s, Poulsen HE, Brosen K. (1996) .Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine, and paroxetine. Eur<\/u> J <\/u>Clin<\/u> Pharmacol. <\/u><\/em>\u00a051<\/em>(1):73-78<\/p>\n

    Juan A. Carrillo and Julio Benitez. (2000) \u201cClinically Significant Pharmacokinetic Interactions Between Caffeine and Medications,\u201d Clinical<\/u> Pharmacokinetics<\/u>,\u00a039<\/em>(2); 127-153<\/p>\n

    Goodman & Gilman. (2009). Tedavinin Farmakolojik Temelleri.<\/em> Metilksantinler, s. 336, 727-730, 920. \u00c7eviri Edit\u00f6r\u00fc: S\u00fczer \u00d6.Nobel T\u0131p Kitabevleri Ltd. \u015eti., \u0130stanbul<\/p>\n

    Nawrot P, Jordan S, Eastwood J, Rotstein J, Hugenholtzand A, Feeley M. (2003). Effects of caffeine on human health. Food Additives and Contaminants<\/em> 20<\/em>(1): 1-30.<\/p>\n

    Geleijnse JM. (2008). Habitual coffee consumption and blood pressure: an epidemiological perspective. Vascular Health and Risk Management, 4<\/em>(5):963-70.<\/p>\n

    .Bonita JS, Mandarano M, Shuta D, Vinson J. (2007). Coffee, and Cardiovascular disease: Invitro, cellular, animal, and human studies. Pharmacological Research, 55<\/em>(3):187-98.<\/p>\n

    \u00c7AKIR ERC\u0130L. (2010, December). Kafein: Kafein Kaynaklaro, Besinlerdeki Kafein Miktarlar\u0131 ve Kafeinin Zararlar\u0131<\/i>. Dyt.Sernaz \u00c7AKIR ERC\u0130L. http:\/\/www.tavsiyeediyorum.com\/makale_6059.htm<\/p>\n

    Lowry, N. (n.d.). Tea and theophylline<\/i>. Helios.Hampshire. Retrieved 2021, from http:\/\/helios.hampshire.edu\/~nlNS\/mompdfs\/TeaTheoph.pdf<\/p>\n

    \u00c7ay Bitkisinin \u00d6zellikleri \u00bb .:: Rize Ziraat Odas\u0131 ::.<\/i> (2015, March 17). Rize Ziraat Odasi. http:\/\/rizeziraatodasi.com\/cay-bitkisinin-ozellikleri\/<\/p>\n

    \u00a0<\/b><\/p>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    Caffeine, which we take from many foods in our daily lives,even in small amounts, can affect our medications when it reaches certain doses. So, what is caffeine? How does it affect the body? How can it change the effects of drugs? For answers, keep reading. What is caffeine? Caffeine is one of the most widely<\/p>\n","protected":false},"author":41,"featured_media":10605,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18,1,20],"tags":[2142,467,81,2141,1355],"yst_prominent_words":[],"class_list":["post-10592","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-culture","category-general","category-science","tag-caffeine","tag-general","tag-health","tag-medications","tag-pharmacology"],"_links":{"self":[{"href":"https:\/\/mozartcultures.com\/en\/wp-json\/wp\/v2\/posts\/10592","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mozartcultures.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mozartcultures.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mozartcultures.com\/en\/wp-json\/wp\/v2\/users\/41"}],"replies":[{"embeddable":true,"href":"https:\/\/mozartcultures.com\/en\/wp-json\/wp\/v2\/comments?post=10592"}],"version-history":[{"count":12,"href":"https:\/\/mozartcultures.com\/en\/wp-json\/wp\/v2\/posts\/10592\/revisions"}],"predecessor-version":[{"id":10785,"href":"https:\/\/mozartcultures.com\/en\/wp-json\/wp\/v2\/posts\/10592\/revisions\/10785"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mozartcultures.com\/en\/wp-json\/wp\/v2\/media\/10605"}],"wp:attachment":[{"href":"https:\/\/mozartcultures.com\/en\/wp-json\/wp\/v2\/media?parent=10592"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mozartcultures.com\/en\/wp-json\/wp\/v2\/categories?post=10592"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mozartcultures.com\/en\/wp-json\/wp\/v2\/tags?post=10592"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/mozartcultures.com\/en\/wp-json\/wp\/v2\/yst_prominent_words?post=10592"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}